Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 8, 2025

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
08:29

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Published on: February 1, 2019

10.1K

Aptamer-functionalized liposomes for drug delivery.

Ka-Ying Wong1, Man-Sau Wong2, Juewen Liu1

  • 1Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Canada; Centre for Eye and Vision Research (CEVR), Pak Shek Kok, Shatin, Hong Kong.

Biomedical Journal
|December 11, 2023
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Guanine-Rich DNA Aptamers for Selective Binding to Agarose Hydrogels.

Bioconjugate chemistry·2026
Same author

Capture-SELEX-Derived Low-Nanomolar-Affinity Aptamers for Doxorubicin and Inhibition of Cellular Uptake.

ACS chemical biology·2026
Same author

Enzymes, DNAzymes and nanozymes for environmental remediation.

Nanoscale·2026
Same author

Combining G-Quadruplex and Non-Quadruplex Aptamers with Distinct Thermodynamic Driving Forces for Highly Selective Pb<sup>2+</sup> Detection.

ACS sensors·2026
Same author

Capture-SELEX derived aptamers for light-up fluorescent detection of carbendazim.

Talanta·2026
Same author

Affinity sensors for L-lactate and lactate dehydrogenase.

Analytical methods : advancing methods and applications·2026

Aptamer-functionalized liposomes offer advanced targeted drug delivery due to aptamers

Area of Science:

  • Biotechnology and Nanomedicine
  • Drug Delivery Systems
  • Molecular Targeting

Background:

  • Aptamers offer advantages over antibodies as targeting ligands, including smaller size and ease of modification.
  • Liposomes are a well-established drug delivery vehicle, with many FDA-approved formulations.
  • Targeted drug delivery aims to improve therapeutic efficacy and reduce side effects.

Purpose of the Study:

  • To review aptamer-functionalized liposomes for targeted drug delivery, focusing on non-cancer applications.
  • To discuss aptamer selection, conjugation methods, and in vivo behavior of aptamer-liposome conjugates.
  • To explore future research opportunities and challenges in aptamer-based drug delivery.

Main Methods:

  • Review of scientific literature on aptamer selection and aptamer-liposome conjugation techniques.
Keywords:
AptamersEyeLiposomesTargeted drug deliveryTumors

More Related Videos

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells
10:02

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells

Published on: June 10, 2022

2.2K
Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

23.1K

Related Experiment Videos

Last Updated: Jul 8, 2025

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
08:29

Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA

Published on: February 1, 2019

10.1K
Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells
10:02

Using Lipid Nanoparticles for the Delivery of Chemically Modified mRNA into Mammalian Cells

Published on: June 10, 2022

2.2K
Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform
09:41

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

23.1K
  • Analysis of in vivo studies detailing the fate and efficacy of aptamer-liposome conjugates.
  • Compilation of recent applications of aptamer-functionalized liposomes beyond cancer therapy.

    • Main Results:

    • Aptamers can be selected to target diverse cell surface biomarkers, enabling specific drug delivery.
    • Various methods exist for conjugating aptamers to liposomes, influencing conjugate stability and targeting efficiency.
    • Aptamer-liposome conjugates show potential in various applications, including direct tissue application (e.g., intratumoral, ocular).

    Conclusions:

    • Aptamer-functionalized liposomes represent a promising platform for targeted drug delivery across various medical fields.
    • Further research is needed to address challenges in aptamer targeting and optimize conjugate design for clinical translation.
    • The review highlights emerging applications and future directions for this advanced drug delivery technology.