The comprehensive review about elements accumulation in industrial hemp (Cannabis sativa L.)

Cannabis sativa L., commonly known as industrial hemp, is a versatile plant with applications ranging from medicinal to agricultural and industrial uses. Despite its benefits, there is a notable gap in regulatory toxicology, in understanding the extent of element accumulation in hemp, which is critical due to its ability to absorb various elements from the soil, including heavy metals (Pb, Cd, Hg, and As), uptakes potential toxic elements (e.g., Sb, Sn, Sr, Bi, Tl), problematic elements (Ni, Cr, Co), and essential elements (Zn, Cu, Fe, Mn). The paper aims to enrich current understandings by offering a comprehensive analysis of elements absorption in industrial hemp. This study emphasizes the potential health risks linked with hemp consumption including regulatory toxicology aspects: limits, Permitted Daily Exposures (PDE), recommendations in different countries and from different agencies/bodies (like the WHO and the EU) based on route of administration, jurisdiction and actual literature review. This review contributes significantly to the knowledge base on hemp safety, serving as a valuable resource for researchers, regulatory bodies, and industry stakeholders.