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A counter-swirl design concept for dry powder inhalers
Vishal Chaugule1, Larissa Gomes Dos Reis2, David F Fletcher3
1Laboratory for Turbulence Research in Aerospace and Combustion (LTRAC), Department of Mechanical and Aerospace Engineering, Monash University, Clayton Campus, Melbourne, Australia.
International Journal of Pharmaceutics
|December 11, 2023
Summary
A novel grid-free dry powder inhaler (DPI) design uses a counter-swirl airflow to reduce drug loss. This innovative DPI design shows a 20% reduction in drug deposition compared to traditional designs.
Area of Science:
- Pharmaceutical Technology
- Aerosol Science
- Biomedical Engineering
Background:
- Dry powder inhalers (DPIs) often use swirling airflow for de-agglomeration.
- Flow-straightening grids are typically needed to minimize drug loss from lateral aerosol spreading.
- Existing DPI designs face challenges with drug deposition loss.
Purpose of the Study:
- To introduce and evaluate a novel grid-free DPI design.
- To improve aerosol flow characteristics and reduce drug deposition loss.
- To investigate the efficacy of a counter-swirl airflow mechanism.
Main Methods:
- Computational fluid dynamics (CFD) simulations.
- Particle image velocimetry (PIV) measurements.
- In-vitro deposition studies using a next-generation impactor (NGI).
Main Results:
- The counter-swirl DPI demonstrated 20% less drug deposition in the NGI induction port and pre-separator compared to a baseline DPI.
- Reduced flow-swirl in the counter-swirl DPI eliminated axial reverse flow and decreased lateral aerosol spreading.
- Modified counter-swirl designs, while preventing inlet loss, showed increased deposition due to higher flow-swirl.
Conclusions:
- The grid-free counter-swirl DPI design effectively reduces drug deposition loss.
- Counter-swirl airflow is a promising strategy for optimizing DPI performance.
- Fine particle fraction remains consistent across tested DPI designs.
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