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Higher intraocular pressure is associated with slower axial growth in children with non-pathological high myopia

Fabian Sl Yii1,2, Mingguang He3,4,5, Francesca Chappell6

  • 1Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK. fabian.yii@ed.ac.uk.

Eye (London, England)
|December 11, 2023
PubMed

Insights

Higher intraocular pressure (IOP) is linked to slower axial elongation in children with high myopia. This finding suggests ocular compliance may influence IOP and myopia progression in pediatric high myopia.

Area of Science:

  • Ophthalmology
  • Pediatric Ophthalmology
  • Myopia Research

Background:

  • High myopia in children is a growing concern.
  • Understanding factors influencing axial elongation is crucial for myopia management.
  • Intraocular pressure (IOP) is a potential, yet understudied, factor in pediatric high myopia progression.

Purpose of the Study:

  • To investigate the association between intraocular pressure (IOP) and the rate of axial elongation in children with high myopia.
  • To explore the relationship between IOP and axial length (AL) contemporaneously.

Main Methods:

  • A longitudinal study of 81 children (162 eyes) aged 7-12 years with high myopia.
  • Utilized a linear mixed-effects model (LMM) to analyze data over five biennial visits (mean follow-up 5.2 years).
  • Controlled for covariates including sex, age, central corneal thickness, anterior chamber depth, and lens thickness.

Main Results:

  • Higher IOP was significantly associated with a slower rate of axial elongation (β = -0.01, p = 0.001).
  • A positive contemporaneous association was found between IOP and axial length (AL) (β = 0.03, p = 0.004).
  • This IOP-AL association weakened with increasing age, indicated by a significant interaction effect (β = -0.01, p = 0.001).

Conclusions:

  • Elevated intraocular pressure correlates with reduced axial growth in children experiencing high myopia.
  • The findings suggest that ocular compliance might play a confounding role in the observed IOP-IOP association.
  • This research contributes to understanding the complex interplay of factors influencing myopia progression in children.
Abstract

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