Alzheimer's Together with Mild Cognitive Impairment Screening Using Polar Transformation of Middle Zone of Fundus...

Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) are considered an increasing major health problem in elderlies. However, current clinical methods of Alzheimer's detection are expensive and difficult to access, making the detection inconvenient and unsuitable for developing countries such as Thailand. Thus, we developed a method of AD together with MCI screening by fine-tuning a pre-trained Densely Connected Convolutional Network (DenseNet-121) model using the middle zone of polar transformed fundus image. The polar transformation in the middle zone of the fundus is a key factor helping the model to extract features more effectively and that enhances the model accuracy. The dataset was divided into 2 groups: normal and abnormal (AD and MCI). This method can classify between normal and abnormal patients with 96% accuracy, 99% sensitivity, 90% specificity, 95% precision, and 97% F1 score. Parts of both MCI and AD input images that most impact the classification score visualized by Grad-CAM++ focus in superior and inferior retinal quadrants.Clinical relevance- The parts of both MCI and AD input images that have the most impact the classification score (visualized by Grad-CAM++) are superior and inferior retinal quadrants. Polar transformation of the middle zone of retinal fundus images is a key factor that enhances the classification accuracy.