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Updated: Jul 8, 2025

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
Published on: June 26, 2013
Hyperlocal Spatial Flows in BOLD fMRI Expose Novel Brain-Based Correlates of Schizophrenia
Abstract:
While analysis of temporal signal fluctuations has long been a fixture of blood oxygenation-level dependent (BOLD) functional magnetic resonance imaging (fMRI) research, the role of spatially localized directional diffusion in both signal propagation and emergent large-scale functional integration remains almost entirely neglected. We are proposing an extensible framework to capture and analyze spatially localized fMRI directional signal flow dynamics. The approach is validated in a large resting-state fMRI schizophrenia study where it uncovers significant and novel relationships between hyperlocal spatial dynamics and subject diagnostic status.
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