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Updated: Jul 8, 2025

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
Published on: April 23, 2021
Advances in breast cancer risk modeling: integrating clinics, imaging, pathology and artificial intelligence for
Filippo Pesapane1, Ottavia Battaglia2, Giuseppe Pellegrino2
1Breast Imaging Division, IEO European Institute of Oncology IRCCS, Milan, 20141, Italy.
Abstract:
Breast cancer risk models represent the likelihood of developing breast cancer based on risk factors. They enable personalized interventions to improve screening programs. Radiologists identify mammographic density as a significant risk factor and test new imaging techniques. Pathologists provide data for risk assessment. Clinicians conduct individual risk assessments and adopt prevention strategies for high-risk subjects. Tumor genetic testing guides personalized screening and treatment decisions. Artificial intelligence in mammography integrates imaging, clinical, genetic and pathological data to develop risk models. Emerging imaging technologies, genetic testing and molecular profiling improve risk model accuracy. The complexity of the disease, limited data availability and model inputs are discussed. A multidisciplinary approach is essential for earlier detection and improved outcomes.
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