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Peri-implantitis Diagnosis and Prognosis Using Biomarkers: A Systematic Literature Review
The International Journal of Oral & Maxillofacial Implants
|December 12, 2023
Summary
Biomarker levels in saliva and peri-implant crevicular fluid (PICF) can help assess peri-implantitis (PI). Interleukin-1 beta (IL-1β) and Receptor Activator of Nuclear Factor kappa-B Ligand (RANKL) show potential for diagnosing these inflammatory conditions.
Area of Science:
- Biomarker analysis in oral health
- Periodontology and implantology research
Background:
- Peri-implantitis (PI) is a growing concern in dental implantology.
- Saliva and peri-implant crevicular fluid (PICF) are accessible sources for diagnostic biomarkers.
Conclusions:
- Interleukin-1 beta (IL-1β) and Receptor Activator of Nuclear Factor kappa-B Ligand (RANKL) show the most promise for diagnosing peri-implant inflammatory conditions.
- Observed differences in IL-1β and RANKL levels across HI, PIM, and PI groups suggest diagnostic potential.
- Further research is needed to provide robust evidence for these biomarkers in clinical assessment.

