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Elimination of sodium hyaluronate-induced decrease in outflow facility with hyaluronidase.

S R Hein, R H Keates, P A Weber

    Ophthalmic Surgery
    |November 1, 1986
    PubMed
    Summary
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    Intraocular sodium hyaluronate can increase eye pressure by clogging the trabecular meshwork. Hyaluronidase enzyme effectively breaks down hyaluronate, preventing this pressure rise without causing harm.

    Area of Science:

    • Ophthalmology
    • Biochemistry

    Background:

    • Intraocular sodium hyaluronate use can lead to increased intraocular pressure (IOP).
    • This IOP rise is hypothesized to result from trabecular meshwork obstruction by large hyaluronate molecules.

    Purpose of the Study:

    • To quantify the reduction in ocular outflow facility caused by intraocular sodium hyaluronate.
    • To evaluate the efficacy of hyaluronidase in preventing hyaluronate-induced outflow facility changes.
    • To assess the safety profile of hyaluronidase in vivo.

    Main Methods:

    • Serial tonographic measurements were performed in an animal model to assess outflow facility.
    • Hyaluronidase was administered to investigate its effect on hyaluronate-induced changes.
    • Histopathological examination was conducted to evaluate for adverse effects.

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    Main Results:

    • A decrease in outflow facility was documented following intraocular sodium hyaluronate administration.
    • Hyaluronidase treatment successfully cleaved hyaluronate into smaller fragments.
    • The administration of hyaluronidase prevented the reduction in outflow facility.
    • No harmful histopathological side effects were observed.

    Conclusions:

    • Hyaluronidase is effective in preventing the increase in intraocular pressure associated with sodium hyaluronate.
    • Hyaluronidase offers a potential therapeutic strategy to mitigate IOP elevation after procedures using sodium hyaluronate.
    • The enzyme hyaluronidase demonstrates a favorable safety profile for intraocular use.