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Updated: Jul 8, 2025

Measurement of the Pressure-volume Curve in Mouse Lungs
Published on: January 27, 2015
Setting positive end-expiratory pressure: using the pressure-volume curve
Francesco Mojoli1,2, Marco Pozzi2, Eric Arisi2
1Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, Unit of Anesthesia and Intensive Care, University of Pavia, Pavia, Italy.
The pressure-volume (PV) curve is a valuable bedside tool for optimizing mechanical ventilator settings. It helps assess lung recruitability and reduce ventilator-induced lung injury by fine-tuning positive end-expiratory pressure (PEEP).
Area of Science:
- Respiratory mechanics
- Mechanical ventilation
- Critical care medicine
Background:
- The pressure-volume (PV) curve is a key tool in respiratory physiology.
- Understanding lung elastic properties is crucial for mechanical ventilation.
- Ventilator-induced lung injury (VILI) remains a significant concern.
Conclusions:
- The PV curve is an accessible bedside tool for interpreting lung mechanics.
- Correct interpretation aids in selecting optimal positive end-expiratory pressure (PEEP) strategies.
- Further clinical studies are needed to confirm if PV curve-guided ventilation improves patient outcomes.
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