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Updated: Jul 8, 2025
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Published on: November 2, 2014
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Ovarian Mesonephric-like Adenocarcinoma Recurring With a Rhabdomyosarcoma Component: A Case Report
Summary
This study details the first reported case of ovarian mesonephric-like adenocarcinoma (MLA) recurring as a rapidly growing carcinosarcoma. Genomic analysis confirmed an identical KRAS mutation in both the primary and recurrent tumors.
Area of Science:
- Gynecologic Oncology
- Pathology
- Genomic Medicine
Background:
- Mesonephric-like adenocarcinoma (MLA) is a rare tumor typically found in the endometrium or ovaries, mimicking mesonephric adenocarcinoma of the cervix.
- This report focuses on a unique case of ovarian MLA with aggressive recurrence.
Observation:
- A patient diagnosed with stage IVB ovarian MLA experienced a rapid recurrence 15 months post-treatment.
- The recurrent tumor was a large, rapidly growing abdominal mass with a sarcomatous component.
Findings:
- Histological and immunohistochemical analysis revealed the recurrent tumor to be a carcinosarcoma with rhabdomyosarcomatous features.
- Genomic profiling identified an identical KRAS mutation in both the primary ovarian MLA and the recurrent carcinosarcoma, suggesting a clonal relationship.
Implications:
- This case highlights the potential for ovarian MLA to undergo sarcomatous transformation and aggressive recurrence.
- Understanding the genomic underpinnings, such as KRAS mutations, may inform future therapeutic strategies for this rare malignancy.
