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Updated: Jul 8, 2025
Author Spotlight: Unlocking Insights into the Immune Cell Landscape of Tumors
Published on: August 18, 2023
Systems immunology spanning tumors, lymph nodes, and periphery
Dimitrios N Sidiropoulos1, Won Jin Ho2, Elizabeth M Jaffee2
1Johns Hopkins University School of Medicine, Baltimore, MD, USA; Johns Hopkins Convergence Institute, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA; Johns Hopkins Bloomberg Kimmel Institute for Immunotherapy, Johns Hopkins Medicine, Baltimore, MD, USA; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, MD, USA.
Understanding how immune cells, or leukocytes, move throughout the body is key to understanding cancer progression and treatment response. This review explores methods to study leukocyte trafficking and adaptive immunity in cancer.
Area of Science:
- Immunology and Cancer Biology
- Systems Biology
- Computational Biology
Background:
- The immune system is a complex network of cells and tissues dynamically coordinating responses.
- Interactions between immune and cancer cells influence disease progression.
- Lymphocyte trafficking and interactions with tumor cells are critical for therapeutic outcomes.
Purpose of the Study:
- To review experimental and computational methods for studying leukocyte trafficking.
- To highlight the role of immunomics in understanding adaptive immunity in cancer.
- To elucidate how adaptive immunity shapes cancer progression.
Main Methods:
- Experimental techniques for tracking leukocyte movement.
- Computational approaches for systems-level analysis of immune dynamics.
- Immunomics-based strategies to study immune cell behavior.
Main Results:
- Leukocyte trafficking is a critical factor in cancer progression and therapeutic response.
- A systems-level approach is necessary for a comprehensive understanding of lymphocyte dynamics.
- Adaptive immunity significantly shapes the cancer landscape.
Conclusions:
- Studying leukocyte trafficking through an immunomics lens provides crucial insights into cancer.
- Understanding lymphocyte dynamics is essential for developing effective cancer therapies.
- Integrated experimental and computational methods advance cancer immunology research.
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