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Pediatric long-term noninvasive respiratory support in children with central nervous system disorders

Marion Carrara1, Guillaume Aubertin1,2,3, Sonia Khirani4,5,6

  • 1Department of Pediatric Pulmonology, AP-HP, Hôpital Armand Trousseau, Paris, France.

Pediatric Pulmonology
|December 13, 2023
PubMed

Insights

Long-term noninvasive respiratory support, including continuous positive airway pressure (CPAP) and noninvasive ventilation (NIV), is increasingly used for pediatric central nervous system (CNS) disorders. This study characterized French children with CNS disorders receiving this support, finding it a viable therapeutic option.

Area of Science:

  • Pediatric Pulmonology
  • Neurology
  • Respiratory Medicine

Background:

  • The use of long-term noninvasive respiratory support is rising in pediatric populations.
  • Indications are expanding, particularly for children with central nervous system (CNS) disorders.

Purpose of the Study:

  • To characterize children with CNS disorders undergoing long-term noninvasive respiratory support in France.
  • To describe patient demographics, underlying CNS conditions, and support modalities.

Main Methods:

  • Data collected from 27 French pediatric university centers via anonymous questionnaires.
  • Included children on noninvasive ventilatory support for ≥3 months as of June 1, 2019.
  • Focused on patient characteristics, support type, and adherence.

Main Results:

  • 182 patients (median age 10.2 years) with various CNS disorders were analyzed.
  • 75% received noninvasive ventilation (NIV), 25% continuous positive airway pressure (CPAP).
  • Nasal masks were common, with median adherence of 8 hours/night.

Conclusions:

  • Continuous positive airway pressure (CPAP) and noninvasive ventilation (NIV) represent a therapeutic option for pediatric CNS disorders.
  • Further research is needed to evaluate treatment efficacy and patient-reported outcomes.
Abstract

Keywords:
airway clearancecentral nervous system disorderchildrencontinuous positive airway pressuremultiple disabilitiesnoninvasive ventilation

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