The value of multiparametric MRI radiomics in predicting IDH genotype in glioma before surgery

To explore the value of multiparametric magnetic resonance imaging(MRI) radiomics in the preoperative prediction of isocitrate dehydrogenase (IDH) genotype for gliomas.

The preoperative routine MRI sequences of 114 patients with pathologically confirmed grade II-IV gliomas were retrospectively analysed. All patients were randomly divided into training cohort(n=79) and validation cohort(n=35) in the ratio of 7:3. After feature extraction, we eliminated covariance by calculating the linear correlation coefficients between features, and then identified the best features using the F-test. The Logistic regression was used to build the radiomics model and the clinical model, and to build the combined model. Assessment of these models by subject operating characteristic (ROC) curves, area under the curve (AUC), sensitivity and specificity.

The multiparametric radiomics model was built by eight selected radiomics features and yielded AUC values of 0.974 and 0.872 in the training and validation cohorts, which outperformed the conventional models. After incorporating the clinical model, the combined model outperformed the radiomics model, with AUCs of 0.963 and 0.892 for the training and validation cohorts.

Radiomic models based on multiparametric MRI sequences could help to predict glioma IDH genotype before surgery.