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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
Published on: October 6, 2022
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Pain management research from the NIH HEAL Initiative.
Barbara Illowsky Karp1, Rebecca G Baker2
1Division of Clinical Research, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
Frontiers in Pain Research (Lausanne, Switzerland)
|December 13, 2023
Summary
The National Institutes of Health (NIH) Helping to End Addiction Long-term® (HEAL) Initiative funds research for non-addictive pain treatments. This initiative aims to combat the opioid crisis through prevention and treatment strategies.
Area of Science:
- Pain research
- Addiction science
- Translational medicine
Background:
- The opioid crisis remains a significant public health challenge.
- Existing pain management often relies on addictive medications.
- There is a critical need for non-addictive pain treatment alternatives.
Purpose of the Study:
- To provide an overview of the research programs within the NIH HEAL Initiative.
- To highlight HEAL's focus on developing non-addictive pain therapies.
- To describe the scope of HEAL-funded research from discovery to clinical practice.
Main Methods:
- The article reviews the research portfolio of the NIH HEAL Initiative.
- It outlines the initiative's approach to addiction prevention and treatment.
- It details the progression of research from early-stage discovery to clinical application.
Main Results:
- The NIH HEAL Initiative supports a broad spectrum of pain research.
- Key research areas include therapeutic discovery, development, and clinical trials.
- The initiative emphasizes translating research findings into clinical practice.
Conclusions:
- The NIH HEAL Initiative is a comprehensive program addressing the opioid crisis.
- It prioritizes the development of effective, non-addictive pain management solutions.
- HEAL's research aims to improve patient outcomes and reduce opioid misuse.
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