Intra-nucleus accumbens amphetamine: dose-dependent effects on food intake

The effects of microinjections into the nucleus accumbens (N.ACC.) of 0.0, 2.0 or 8.0 micrograms of (+)-amphetamine sulphate (AMPH) on food intake and running wheel activity were examined. The 2.0 micrograms dose of AMPH produced increased food intake while 8.0 micrograms significantly decreased food intake. No effect was found on running wheel activity with the 2.0 micrograms dose, though 8.0 micrograms significantly increased the number of wheel revolutions with respect to the saline group. Results were interpreted to suggest that the N.ACC. may be an important site in the mediation of the increased food intake noted with low doses of psychomotor stimulants.