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Serum magnesium level and cardiac valve calcification in hemodialysis patients
Shihming Tsai1, Yuehong Li2, Xianglan Wu1
1Department of Nephrology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, 168 Litang Road, Changping District, Beijing, 102218, China.
Insights
Low magnesium levels are linked to cardiac valve calcification in hemodialysis patients. This finding highlights the importance of monitoring magnesium and calcium levels in this population.
Area of Science:
- Nephrology
- Cardiology
- Biochemistry
Background:
- Cardiac valve calcification is a significant complication in patients undergoing maintenance hemodialysis.
- It is closely associated with increased cardiovascular disease risk.
Purpose of the Study:
- To investigate the relationship between serum magnesium levels and the prevalence of cardiac valve calcification in hemodialysis patients.
- To identify clinical factors associated with cardiac valve calcification in this cohort.
Main Methods:
- A cross-sectional study involving 105 maintenance hemodialysis patients.
- Echocardiography was used to assess cardiac valve calcification.
- Clinical data, including electrolytes and parathyroid hormone, were analyzed.
Main Results:
- Over 64% of patients exhibited cardiac valve calcification.
- Cardiac valve calcification was associated with older age, diabetes mellitus, and coronary artery calcification.
- Lower levels of serum magnesium, serum calcium, and parathyroid hormone were observed in patients with valve calcification.
Conclusions:
- Cardiac valve calcification in hemodialysis patients is associated with age, serum calcium, and notably, lower serum magnesium levels.
- These findings underscore the clinical importance of monitoring magnesium and calcium levels in hemodialysis patients to potentially mitigate cardiac valve calcification.
Introduction:
Cardiac valve calcification is closely related to cardiovascular disease. The aim of this study was to investigate the magnesium level and cardiac valve calcification in hemodialysis patients.
Methods:
A cross-sectional study was conducted in 105 maintenance hemodialysis patients with complete follow-up data from June 2020 to May 2021 in Beijing Tsinghua Changgung Hospital, Tsinghua University. Baseline data, including sex, age, primary disease, liver and kidney function, electrolytes and parathyroid hormone, were recorded. According to their echocardiograms, patients were divided into a cardiac valve calcification group and a noncardiac valve calcification group, and the correlations between valve calcification and clinical data were analyzed.
Results:
Of 105 patients under hemodialysis, 60 (56.6%) were male, with an average age of 62.1 ± 13.5 years and a mean dialysis duration of 58.8 ± 45.4 months. The majority of primary renal diseases were diabetic nephropathy (55, 51.9%). Approximately 64.8% of the 105 maintenance hemodialysis patients had cardiac valve calcification, and 35.2% were in the noncardiac valve calcification group. The independent t test and the chi-square test analysis showed that the cardiac valve calcification group had older age, higher smoking rate, diabetes mellitus, lower extremity arterial occlusion, coronary heart disease, and coronary artery calcification ratio but lower parathyroid hormone, serum calcium, serum magnesium, albumin, prealbumin, and high-density lipoprotein cholesterol levels (P < 0.05). Logistic regression analysis showed that age, diabetes mellitus, coronary artery calcification, lower serum magnesium, lower serum calcium, and lower parathyroid hormone levels were associated with valve calcification.
Conclusion:
The presence of cardiac valve calcification was associated with age, calcium, phosphorus and lower magnesium level. These factors we should pay more attention in clinical practice.
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