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Related Concept Videos

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
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T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
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Decoding immunogenic cell death from a dendritic cell perspective.

Sophie Janssens1,2, Sofie Rennen1,2, Patrizia Agostinis3

  • 1Laboratory for ER Stress and Inflammation, Center for Inflammation Research, VIB, Ghent, Belgium.

Immunological Reviews
|December 14, 2023
PubMed
Summary
This summary is machine-generated.

Immunogenic cell death (ICD) in cancer cells, marked by danger signals called damage-associated molecular patterns (DAMPs), is crucial for dendritic cell (DC) maturation and activating anti-tumor immunity. This interaction bridges innate and adaptive immunity for cancer defense.

Keywords:
antitumor immunitydamage-associated molecular patternsdendritic cellsimmunogenic cell deathinflammation

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An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
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Area of Science:

  • Immunology
  • Cancer Biology
  • Cell Death

Background:

  • Dendritic cells (DCs) are key myeloid cells connecting innate and adaptive immunity.
  • DCs present tumor-associated antigens (TAAs) to T cells, playing a vital role in the cancer immunity cycle.
  • Tumor cell death must release immunomodulatory signals, not just TAAs, for effective DC maturation.

Purpose of the Study:

  • To review how dendritic cells (DCs) recognize and interpret danger signals from cancer cells undergoing immunogenic cell death (ICD).
  • To explore the consequences of DC-cancer cell interaction on DC function and anti-tumor immunity.

Main Methods:

  • Review of existing literature on immunogenic cell death (ICD), damage-associated molecular patterns (DAMPs), and dendritic cell (DC) function in cancer.
  • Analysis of signaling pathways involved in DC perception of DAMPs released by dying cancer cells.

Main Results:

  • Immunogenic cell death (ICD) in cancer cells, characterized by pathogen-mimicry and DAMP release, is essential for immunogenic DC maturation.
  • DCs perceive DAMPs from ICD cells, leading to their maturation and effective presentation of TAAs to T cells.
  • This interaction promotes the engagement of adaptive immunity against cancer.

Conclusions:

  • The ability of cancer cells to undergo ICD and release DAMPs is critical for eliciting a potent anti-tumor immune response via dendritic cells.
  • Understanding DC recognition of ICD signals offers therapeutic strategies to enhance anti-tumor immunity.