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Atopic Dermatitis in the Elderly Population.

Martina Maurelli1, Andrea Chiricozzi2, Ketty Peris2

  • 1Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy. maurelli.martina@gmail.com.

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|December 14, 2023
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Summary
This summary is machine-generated.

Atopic dermatitis affects adults and the elderly, causing severe itch and impacting quality of life. Biologics targeting interleukin-4/-13 are effective for moderate-to-severe cases in older adults.

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Area of Science:

  • Dermatology
  • Immunology
  • Geriatrics

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition with relapsing courses.
  • While often considered a childhood disease, AD is prevalent in adults and the elderly.
  • AD presents with eczematous lesions, severe itch, and significant impacts on daily life and sleep.

Purpose of the Study:

  • To highlight the prevalence and impact of atopic dermatitis in the elderly population.
  • To emphasize the importance of comprehensive disease assessment in older adults.
  • To discuss appropriate treatment strategies for atopic dermatitis in the elderly.

Main Methods:

  • Review of current literature on atopic dermatitis in adult and elderly populations.
  • Analysis of disease burden factors including localization, itch severity, sleep, quality of life, and comorbidities.
  • Evaluation of treatment options, focusing on biological agents and Janus kinase inhibitors.

Main Results:

  • Atopic dermatitis significantly impacts the quality of life in older adults, often exacerbating comorbid conditions.
  • Comprehensive assessment of AD burden is critical for tailoring effective treatment plans.
  • Biological agents inhibiting the interleukin-4/-13 pathway demonstrate safe and effective treatment for moderate-to-severe AD in the elderly.

Conclusions:

  • Atopic dermatitis is a significant concern in the elderly, necessitating thorough evaluation.
  • Interleukin-4/-13 pathway inhibitors offer a safe and effective therapeutic option for moderate-to-severe AD in this demographic.
  • Janus kinase inhibitors may present safety concerns in the elderly population with atopic dermatitis.