Uncommon Hematogenous Metastasis: Orbital Involvement in Uterine Cervical Cancer
Shunichi Yamaguchi1, Mai Koizumi1, Mamoru Kakuda1
1Department of Obstetrics and Gynecology, Sakai City Medical Center, Sakai, Osaka, Japan.
The American Journal of Case Reports
|December 14, 2023
Summary
Older women over 65 may not receive cervical cancer screening, leading to advanced diagnoses. This case highlights rare orbital metastasis from uterine cervical cancer, effectively treated with radiation therapy, improving quality of life.
Area of Science:
- Oncology
- Ophthalmology
- Radiology
Background:
- Uterine cervical cancer (UCC) screening and HPV vaccination are common, yet older women (>65) may lack access or compliance.
- Older women diagnosed with UCC often present with advanced stages and poor prognoses.
- Metastatic UCC can be hematogenous or lymphatic; orbital metastasis is an extremely rare hematogenous manifestation.
Observation:
- A 70-year-old woman with advanced UCC received radiation therapy (RT).
- Post-RT, she developed skin masses and right exophthalmos due to an orbital mass.
- The orbital mass was diagnosed as UCC metastasis.
Findings:
- Radiation therapy (RT) was administered to the orbital tumor.
- The orbital tumor significantly shrank, and visual symptoms resolved.
- The patient died 7 months post-orbital RT, with no recurrence of eye symptoms.
Implications:
- This case underscores that uterine cervical cancer can present at advanced stages in older women.
- Radiation therapy for orbital metastasis from UCC can be effective in managing symptoms and improving quality of life.
- Highlights the importance of considering metastatic disease in older patients, even with prior treatment.
