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A "Patient-Like" Orthotopic Syngeneic Mouse Model of Hepatocellular Carcinoma Metastasis
Published on: October 24, 2015
Biliary microhamartomas (von Meyenburg complexes), liver metastasis simulators: a series of eight cases
Javier A Teco-Cortes1, Peter Grube-Pagola2, M Esther Gutiérrez-Díaz Ceballos1
1Departamento de Patología, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México.
Background:
Von Meyenburg complexes are benign hamartomatous lesions, they are part of the spectrum of ductal plate malformations. They are rare, reported in 0.35-5.6% of the general population, predominantly in adults, with no clear predilection for sex.
Objective:
To present the clinical characteristics of Von Meyenburg complexes in our region.
Method:
We searched all cases with diagnosis of Von Meyenburg complexes in a period from 2012 to 2022, in our institutions.
Results:
We identified eight cases, with an average age of 59.25 years, with a predominance of females and with one case associated with gastric carcinoma.
Conclusions:
It is important to adequately recognize this entity, since due to its multifocal nature it can easily simulate metastasis, additionally, and its presence does not rule out other synchronous neoplasms.
Insights
Von Meyenburg complexes, rare benign liver lesions, were studied in eight adult cases over ten years. One case showed association with gastric carcinoma, highlighting the need for accurate diagnosis to avoid misinterpretation as metastasis.
Area of Science:
- Hepatobiliary Medicine
- Gastrointestinal Pathology
- Oncology
Background:
- Von Meyenburg complexes are rare, benign hamartomatous lesions.
- They represent a spectrum of ductal plate malformations.
- Prevalence ranges from 0.35-5.6% in the general population, primarily affecting adults.
Purpose of the Study:
- To describe the clinical features of Von Meyenburg complexes in a specific regional cohort.
- To enhance understanding of this rare liver entity.
Main Methods:
- Retrospective analysis of diagnosed Von Meyenburg complex cases.
- Data collected from institutional records between 2012 and 2022.
Main Results:
- Eight cases of Von Meyenburg complexes were identified.
- The average patient age was 59.25 years, with a female predominance.
- One case was associated with concurrent gastric carcinoma.
Conclusions:
- Accurate recognition of Von Meyenburg complexes is crucial.
- Their multifocal nature can mimic metastatic disease.
- The presence of Von Meyenburg complexes does not exclude synchronous neoplasms.
