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Fructose promotes liver cancer via microbial acetate-induced O-GlcNAcylation
Emily M Esquea1, Riley G Young1, Mauricio J Reginato2
1Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, USA.
Trends in Endocrinology and Metabolism: TEM
|December 14, 2023
Abstract:
High dietary fructose consumption is linked to multiple disease states, including cancer. Zhou and colleagues recently reported a novel mechanism where high dietary fructose levels increase acetate production by the gut microbiome increasing post-translational modification O-GlcNAcylation in liver cells, which contributes to disease progression in mouse models of hepatocellular carcinoma.
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