Effects of airway cooling on tracheal stretch receptors

We studied the effect of cold air on tracheal slowly adapting stretch receptors (SAR) in 6 anesthetized, spontaneously breathing dogs. Air at constant flow and two different temperatures was passed through an isolated segment of the extrathoracic trachea. We recorded SAR action potentials, esophageal pressure, tracheal pressure and temperature. With a reduction in tracheal temperature of approximately 10 degrees C the steady state response of 30 SARs to a distending pressure of 1.0 kPa decreased to 75% of control (P less than 0.001). At lower distending pressure the inhibitory effect of tracheal cooling decreased: 87% of control at 0.5 kPa (P less than 0.05, n = 8) and 96% of control at 0.2 kPa (P greater than 0.05, n = 8). The response of 13 tracheal SARs to sinusoidal pressure oscillations (0.15 kPa) superimposed on a bias pressure (0.5 kPa) was reduced (P less than 0.01) by local cooling to the same extent at the 2 pressure extremes ('peak' value = 71% of control; 'valley' = 67% of control), resulting in a similar change in receptor discharge within the oscillatory cycle. The inhibitory effect of airway cooling on stretch receptors may play a role in cold-induced bronchoconstriction.