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The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
Potential application of anti-osteoporotic therapy to relieve sarcopenia in the elderly
YunGui Li1, XiaoBing Li2, ZhaoRong Kong2
1Department of Anesthesiology, The Affiliated Hospital of Kunming University of Science and Technology, Kunming/The First People's Hospital of Yunnan Province.
Abstract:
Sarcopenia is a progressive and systemic skeletal muscle disorder associated with aging that usually occurs with age in the elderly. Sarcopenia currently lacks effective pharmacological treatment modalities. Multiple pharmacological intervention modalities are available for osteoporosis, a comprehensive disease characterized by decreased systemic bone mass, degradation of bone microarchitecture, and increased bone fragility. Several recent studies have shown an extremely strong correlation between sarcopenia and osteoporosis, leading to the concept of "osteosarcopenia". Therefore, it is possible to alleviate sarcopenia simultaneously by improving osteoporosis.
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