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Specific tissue engineering for temporomandibular joint disc perforation.

Ziyang Min1, Yibo Li1, Yichen Xiong1

  • 1West China School/Hospital of Stomatology, Chengdu, China.

Cytotherapy
|December 15, 2023
PubMed
Summary

Temporomandibular joint (TMJ) disc perforation can cause significant oral health issues. Tissue engineering presents promising solutions for repairing damaged TMJ discs, offering hope for regeneration.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Oral and Maxillofacial Surgery

Background:

  • The temporomandibular joint (TMJ) disc is vital for oral function and has limited self-repair capabilities.
  • TMJ disc perforation can lead to severe conditions like osteoarthritis and ankylosis.
  • Current surgical and non-surgical treatments for TMJ disc perforation have uncertain long-term efficacy and limited repair success rates.

Purpose of the Study:

  • To review the classification and definition of temporomandibular joint (TMJ) disc perforation.
  • To summarize advancements in tissue engineering approaches for TMJ disc repair.
  • To discuss challenges hindering the clinical application of these regenerative technologies.

Main Methods:

  • Literature review focusing on TMJ disc perforation classification and treatment.
Keywords:
TMJ disc perforationclinical translationscaffoldsseed cellstissue engineering

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  • Analysis of current tissue engineering strategies including stem cell therapy and scaffold development.
  • Discussion of barriers to the widespread adoption of engineering-based TMJ disc repair.

    • Main Results:

    • TMJ disc perforation is a condition with significant clinical implications.
    • Tissue engineering, utilizing stem cells, scaffolds, and bioactive stimuli, shows potential for TMJ disc regeneration.
    • Several technical and clinical barriers impede the popularization of these advanced engineering technologies.

    Conclusions:

    • Tissue engineering offers a potential therapeutic avenue for both repairable and unrepairable TMJ disc perforations.
    • Further research and development are necessary to overcome existing barriers and translate engineering solutions into clinical practice.
    • Regenerative approaches hold promise for improving long-term outcomes in patients with TMJ disc damage.