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Association Areas of the Cortex

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Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...

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Related Experiment Video

Updated: Jul 8, 2025

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Published on: December 12, 2012

A neural circuit for spatial orientation derived from brain lesions.

Moshe Roseman¹, Uri Elias¹, Isaiah Kletenik^2,3,4

¹Neuropsychiatry Lab, Department of Medical Neurosciences, Faculty of Medicine, Hadassah Ein Kerem Campus, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.

Cerebral Cortex (New York, N.Y. : 1991)

|December 15, 2023

Summary

This study maps brain lesions causing topographical disorientation, revealing key navigation network regions including the prefrontal cortex. Findings clarify the brain

Keywords:

connectivity disorientation navigation network space

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Modeling the Functional Network for Spatial Navigation in the Human Brain

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

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Last Updated: Jul 8, 2025

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Published on: December 12, 2012

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

Modeling the Functional Network for Spatial Navigation in the Human Brain

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

Area of Science:

Neuroscience
Cognitive Psychology
Neuroanatomy

Background:

Disagreement exists on the brain networks underlying spatial cognition.
Topographical disorientation, the inability to navigate environments, offers insight into these networks.

Approach:

A lesion mapping approach was used, analyzing 65 published cases of topographical disorientation.
This method identified specific brain regions associated with navigation deficits.

Key Points:

The study delineated a brain map for topographical disorientation, including medial parietal, medial temporal, and temporo-parietal cortices.
A novel finding was the involvement of a ventromedial prefrontal cortex region.
Mapped regions showed correlation with the Default Mode Network sub-network C.

Conclusions:

This research provides causal evidence for the brain's spatial cognitive system.
It demarks major components of the navigation network and identifies previously unrecognized regions.