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Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
Published on: August 9, 2019
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Tertiary lymphoid structures, a historical reappraisal.
1Department of Translational Biomedicine and Neuroscience, University of Bari Medical School, Bari, Italy.
Tissue & Cell
|December 15, 2023
Summary
Tertiary lymphoid structures (TLSs) are organized immune cell clusters in non-lymphoid organs. These structures are implicated in autoimmune diseases, chronic rejection, and cancer.
Area of Science:
- Immunology
- Pathology
Background:
- Tertiary lymphoid structures (TLSs) are aggregates of immune cells found in non-lymphoid tissues.
- TLSs mimic secondary lymphoid organs in cellular composition, organization, and function.
- They feature distinct T and B cell zones, germinal centers, and high endothelial venules (HEVs) expressing Peripheral Node Addressin (PNAD).
Purpose of the Study:
- To define the characteristics and roles of Tertiary Lymphoid Structures (TLSs).
- To explore the association of TLSs with various pathological conditions.
Main Methods:
- Literature review and synthesis of existing research on TLSs.
- Analysis of studies describing TLSs in different disease models.
Main Results:
- TLSs are consistently observed in non-lymphoid organs, mirroring lymph node organization.
- These structures are associated with inflammatory conditions, autoimmune diseases, chronic allograft rejection, and cancer.
Conclusions:
- TLSs are significant micro-environmental components in various diseases.
- Their presence suggests an active immune response within non-lymphoid tissues, impacting disease progression.
Keywords:
Autoimmune diseasesCancerHigh endothelial venulesSecondary lymphoid organsTertiary lymphoid structuresMore Related Videos
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