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Evaluation of trace elements in human lung tissue. I. Concentration and distribution
The Science of the Total Environment
|October 1, 1986
Summary
This study analyzed 27 elements in human lungs, finding two distinct distribution patterns. Some elements were evenly spread, while others, like lead and cadmium, accumulated with age, suggesting inhaled contaminants.
Area of Science:
- Environmental Science
- Toxicology
- Analytical Chemistry
Background:
- Human lung tissue composition is influenced by environmental exposures.
- Understanding trace element distribution is crucial for assessing health impacts.
Purpose of the Study:
- To investigate the distribution of 27 elements in human lung tissue and hilar lymph nodes.
- To identify patterns of element accumulation and their relationship with age and environmental factors.
Main Methods:
- Neutron activation analysis and atomic absorption spectrometry were used to quantify 27 elements.
- Thirteen lung segments and hilar lymph nodes from eight individuals were analyzed.
Main Results:
- Two distinct elemental distribution patterns were observed: homogeneous (Br, Cs, Cu, K, Na, Rb, Se, Zn) and inhomogeneous (Cd, Co, Cr, Pb, Sb, Sc, V).
- Inhomogeneous elements showed increased concentration and inhomogeneity with age.
- Higher concentrations of certain elements were found in lymph nodes compared to lung tissue.
Conclusions:
- Lung tissue exhibits differential accumulation of elements, with some elements increasing with age.
- Elevated levels of specific elements in lungs and lymph nodes suggest enrichment from inhaled atmospheric contaminants.
- Age-related accumulation highlights the long-term impact of environmental pollution on lung health.
