Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Menopause01:28

Menopause

170
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
170
Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Aging01:26

Aging

54
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
54
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

2.6K
Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction...
2.6K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

31
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
31

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Central Systolic Blood Pressure and Left Ventricular Mass: Findings From the International 24-Hour Aortic Blood Pressure Consortium.

Journal of the American Heart Association·2026
Same author

Bridging the divide: GP narratives on lung cancer care in Tasmania.

Australian journal of primary health·2026
Same author

Invasive observation of reactive systolic blood pressure responses to upper-arm cuff inflation.

Journal of human hypertension·2026
Same author

Novel hypertension phenotypes based on cross-classification of 24-h brachial and aortic SBP.

Journal of hypertension·2026
Same author

Exercise blood pressure relative to fitness: pragmatic clinical potential.

European heart journal·2026
Same author

Update from the National Hypertension Taskforce of Australia: prevalence, treatment and control rates of hypertension between 2022 and 2024 - implications and future directions.

Journal of hypertension·2026
Same journal

Intrinsic capacity and the trajectory of ischemic heart disease and its complications: the mediating role of insulin resistance indices.

Maturitas·2026
Same journal

Mobility limitation trajectories and longitudinal changes in delayed recall in midlife and later life: A multicohort study.

Maturitas·2026
Same journal

Digital twins in menopause: a roadmap for integrating endocrine dynamics, multisystem physiology, and precision medicine.

Maturitas·2026
Same journal

Testosterone therapy in women: Keeping pace with the evidence.

Maturitas·2026
Same journal

Diagnosis and management of androgen excess presenting after menopause.

Maturitas·2026
Same journal

Domain-specific severity of menopausal symptoms and emotional eating in midlife women.

Maturitas·2026
See all related articles

Related Experiment Video

Updated: Jul 8, 2025

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.0K

Menopause and accelerated aortic stiffness.

Sheila M O'Neill1, Catherine M Travers2, Petr Otahal3

  • 1Betty Byrne Henderson Women's Health Research Centre, Royal Brisbane & Women's Hospital, Brisbane, Australia; Australian National University, Canberra, Australian Capital Territory, Australia.

Maturitas
|December 15, 2023
PubMed
Summary
This summary is machine-generated.

Menopause transition does not accelerate aortic stiffness, but late postmenopause shows a significant increase. This finding suggests a potential rise in cardiovascular disease risk during later postmenopausal years.

Keywords:
Cardiovascular riskEstrogen replacement therapyHypertensionLongitudinal studyMenopauseVascular aging

More Related Videos

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

10.6K
Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
06:08

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

17.1K

Related Experiment Videos

Last Updated: Jul 8, 2025

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
10:08

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

16.0K
Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

10.6K
Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
06:08

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

Published on: February 7, 2014

17.1K

Area of Science:

  • Cardiovascular Health
  • Women's Health
  • Aging Research

Background:

  • Estrogen is thought to be cardioprotective in women, leading to the belief that menopause increases cardiovascular disease (CVD) risk.
  • Aortic stiffness is a known independent predictor of CVD, but its association with menopause has been unclear.

Purpose of the Study:

  • To investigate the relationship between menopausal status changes and aortic stiffness.
  • To determine if menopause transition accelerates aortic stiffness.

Main Methods:

  • A longitudinal study of Australian women aged 40-80 years (n=469, then n=323) tracked over 14 years.
  • Menopausal status was assessed using the Stages of Reproductive Aging in Women criteria.
  • Aortic stiffness was measured non-invasively using carotid-femoral pulse wave velocity, with statistical analysis accounting for covariates.

Main Results:

  • No association was found between the menopausal transition and accelerated aortic stiffness.
  • A significant acceleration of aortic stiffness (0.122 m/s/year) was observed in the late postmenopause phase (8+ years).
  • This acceleration persisted after controlling for age and traditional cardiovascular risk factors.

Conclusions:

  • The menopausal transition itself does not significantly alter aortic stiffness beyond normal aging.
  • Accelerated aortic stiffness in late postmenopause may elevate cardiovascular risk in this demographic.
  • Further research into managing CVD risk in postmenopausal women is warranted.