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Related Experiment Video

Updated: Jul 8, 2025

Quantifying Bacterial Surface Swarming Motility on Inducer Gradient Plates

Quantifying Bacterial Surface Swarming Motility on Inducer Gradient Plates

Published on: January 5, 2022

Motility-Induced Phase Separation Mediated by Bacterial Quorum Sensing.

Wesley J M Ridgway¹, Mohit P Dalwadi^1,2,3, Philip Pearce^2,3

¹Mathematical Institute, University of Oxford, Oxford OX2 6GG, United Kingdom.

Physical Review Letters

|December 15, 2023

Summary

This summary is machine-generated.

This study explores motility-induced phase separation in active matter, revealing a new MIPS onset criterion linked to genetic networks and identifying novel oscillatory instabilities driven by cell signaling.

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Published on: October 29, 2016

Area of Science:

Biophysics
Systems Biology
Theoretical Biology

Background:

Living active matter exhibits motility-induced phase separation (MIPS).
Cell-cell communication via chemical signaling (quorum sensing) is crucial.
Previous MIPS theories often overlook genetic regulation's role.

Purpose of the Study:

To develop a multiscale continuum model for MIPS incorporating genetic regulation.
To derive a novel criterion for MIPS onset based on genetic network features.
To identify and characterize new oscillatory instabilities in active matter systems.

Main Methods:

Multiscale continuum modeling.
Mathematical analysis.
Computational simulations.

Main Results:

A new MIPS onset criterion dependent on genetic network properties was derived.
A novel oscillatory instability was identified and characterized.
This instability arises when gene regulation promotes motility at higher signal concentrations.

Conclusions:

Genetic regulation significantly influences MIPS dynamics in active matter.
The interplay between gene networks and cell signaling can lead to complex emergent behaviors like oscillations.
This work provides a more comprehensive framework for understanding active matter self-organization.