Related Experiment Video
Updated: Jul 8, 2025
Lateral Chronic Cranial Window Preparation Enables In Vivo Observation Following Distal Middle Cerebral Artery Occlusion in Mice
Published on: December 29, 2016
Functional Outcome and Mortality Predictors in Patients with Cerebral Ischemic Infarction After Decompressive
Amin Rostami1, Daniel Elyassirad2, Mahsa Vatanparast2
1Department of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Insights
Decompressive craniectomy (DC) for ischemic stroke shows a 39.2% survival rate. Larger infarct volume and older age predict poor outcomes and higher mortality following DC surgery.
Area of Science:
- Neurosurgery
- Neurology
- Stroke Medicine
Background:
- Decompressive craniectomy (DC) is a crucial intervention for managing severe cerebral ischemic infarction.
- Long-term functional outcomes after DC remain a subject of debate and require further investigation.
Purpose of the Study:
- To evaluate the long-term functional outcomes of patients who underwent DC for cerebral ischemic infarction.
- To identify predictors of functional outcome and mortality in this patient cohort.
Main Methods:
- A prospective and retrospective cross-sectional study involving 148 patients with cerebral ischemic infarction who underwent DC.
- The Modified Rankin Scale (mRS) was used to assess functional outcomes and disability.
- Demographic and clinical data, including infarct volume, were collected.
Main Results:
- The overall survival rate was 39.2%.
- Higher infarct volume was significantly associated with unfavorable functional outcomes (higher mRS scores) at discharge, 3 months, and final follow-up.
- Older age and larger infarction volume were identified as significant predictors of both mRS scores and mortality.
Conclusions:
- Mortality and functional outcomes (mRS scores) after DC for ischemic stroke are significantly influenced by infarct volume and patient age.
- Infarct volume and older age are critical prognostic factors for patients undergoing DC for ischemic stroke.
Objective:
Surgeons commonly perform Decompressive craniectomy (DC) to manage patients with cerebral ischemic infarction. However, there are conflicting data on the long-term functional outcomes following DC. Therefore, this study aims to determine the functional outcome of patients with cerebral ischemic infarction after DC.
Methods:
This prospective and retrospective cross-sectional study included 148 patients with cerebral ischemic infarction who underwent DC at Ghaem Hospital, Mashhad, Iran, from March 2011 to March 2021. The Modified Rankin Scale (mRS) assesses disability in these patients and determines the recovery and degree of long-term functional outcomes. Demographic and clinical data were extracted and recorded in a researcher-made questionnaire.
Results:
In summary, the follow-up revealed a survival rate of 39.2% among patients with ischemic stroke. The comparison of the mean infarct volume in patients with various mRS scores showed that the mean infarct volume was significantly higher in patients with unfavorable functional outcomes, based on mRS scores at discharge (P = 0.05), 3 months mRS (P < 0.01), and mRS score at final follow-up (P = 0.01). Final mortality was higher in patients with higher mRS scores at discharge, after 3 months, and final follow-up (P < 0.01). Older age and infarction volume can predict mRS and mortality in patients with ischemic stroke (P < 0.01).
Conclusions:
The present study showed that mortality and mRS scores at various times are associated with infarction volume and older age in patients with ischemic stroke.
More Related Videos
09:29Controlled Cortical Impact Model of Mouse Brain Injury with Therapeutic Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Cells
Published on: July 10, 2019
09:11Performing Permanent Distal Middle Cerebral with Common Carotid Artery Occlusion in Aged Rats to Study Cortical Ischemia with Sustained Disability
Published on: February 23, 2016