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Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming
Andrea Cipriano1,2, Mahdi Moqri1,3,4, Sun Y Maybury-Lewis5
1Department of Obstetrics & Gynecology, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
Nature Aging
|December 15, 2023
Summary
Epigenetic rejuvenation using partial reprogramming factors shows promise in combating aging and related diseases in mouse and human models. This approach targets cellular, tissue, and organismal aging, offering new therapeutic avenues.
Area of Science:
- Gerontology and Regenerative Medicine
- Epigenetics and Molecular Biology
Background:
- Aging is a complex process associated with numerous diseases.
- Transient expression of nuclear reprogramming factors offers a novel approach to combat age-related decline.
- Previous studies have demonstrated efficacy in cellular, tissue, and organismal models.
Purpose of the Study:
- To review the current state of epigenetic rejuvenation strategies using partial reprogramming.
- To discuss the role of classical reprogramming factors and adjunct strategies.
- To explore the molecular mechanisms and practical applications of epigenetic reprogramming for aging.
Main Methods:
- Review of existing literature on epigenetic reprogramming and partial reprogramming factors.
- Analysis of studies involving mouse and human model systems.
- Discussion of chromatin remodeling and molecular dynamics in rejuvenation.
Main Results:
- Partial reprogramming effectively combats age-related deterioration across multiple levels.
- Various reprogramming factors and chemical enhancers contribute to rejuvenation.
- Understanding of chromatin remodeling and molecular dynamics is advancing.
Conclusions:
- Epigenetic reprogramming holds significant potential for treating aging and age-related diseases.
- Further research is needed to optimize strategies and address challenges for clinical translation.
- This field is rapidly evolving with promising therapeutic implications.
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