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Factors affecting the early establishment of neonatal intestinal flora and its intervention measures

Guangyu Ma1, Yuguo Shi1, Lulu Meng1

  • 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Frontiers in Cellular and Infection Microbiology
|December 18, 2023
PubMed

Insights

Early intestinal flora is crucial for infant health. This review examines factors influencing neonatal gut microbes and strategies for reconstructing healthy gut microbiota in vulnerable infants.

Area of Science:

  • Microbiology
  • Neonatal Health
  • Gut Microbiome Research

Background:

  • The early-life intestinal flora significantly impacts long-term human health.
  • Understanding the establishment of neonatal gut microbiota is essential for infant well-being.
  • Numerous factors, including maternal, infant, and environmental influences, shape the initial gut microbiome.

Purpose of the Study:

  • To review the mechanisms of intestinal flora colonization in newborns.
  • To discuss factors influencing the establishment of neonatal intestinal flora.
  • To explore methods for reconstructing gut microbiota in infants with colonization defects.

Main Methods:

  • Literature review of studies on neonatal intestinal flora.
  • Analysis of factors such as delivery mode, gestational age, and feeding practices.
  • Examination of strategies for microbiota reconstruction in cesarean-born and premature infants.

Main Results:

  • Delivery mode, gestational age, and feeding methods are key determinants of neonatal gut microbiota composition.
  • Infants born via cesarean section and premature infants often exhibit altered gut microbiota colonization.
  • Both natural and artificial methods can be employed to restore healthy gut flora.

Conclusions:

  • The establishment of neonatal intestinal flora is a complex process influenced by multiple factors.
  • Targeted interventions can address gut microbiota dysbiosis in high-risk infants.
  • Further research can provide a foundation for preventing and treating diseases linked to neonatal gut flora issues.

Keywords:
breast milkcaesarean sectionintestinal floranewbornpremature delivery

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