Related Experiment Video
Updated: Jul 8, 2025
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Association between high-sensitive cardiac troponin level and coronary artery disease: A systematic review and
Alireza Fatemi1, Mahdi Zahedi2, Yasmin Yazdooei1
1Department of Medical Ethics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Insights
High-sensitive cardiac troponin (hs-cTn) levels are significantly associated with coronary artery disease (CAD) risk. This meta-analysis confirms hs-cTn aids in predicting CAD, warranting further mechanistic research.
Area of Science:
- Cardiology
- Biomarkers
- Epidemiology
Background:
- High-sensitive cardiac troponin (hs-cTn) levels are increasingly linked to coronary artery disease (CAD).
- The precise nature of the hs-cTn and CAD association requires clarification.
- Existing evidence necessitates a comprehensive assessment for improved CAD prediction.
Purpose of the Study:
- To systematically review and meta-analyze evidence on the association between hs-cTn levels and CAD.
- To evaluate the predictive value of hs-cTn for CAD.
- To identify potential sources of heterogeneity in the observed associations.
Main Methods:
- Systematic search of four databases and gray literature for relevant studies.
- Quality and risk of bias assessment of included studies.
- Meta-analysis of hs-cTn levels in CAD cases and controls, including subgroup and bias analyses.
Main Results:
- Twenty-two studies with 844 cases and 2101 controls were included.
- Meta-analysis of nine studies revealed a significant positive association between hs-cTn levels and CAD (SMD = 0.44, p < 0.003).
- No significant publication bias was detected (p = 0.9170); subgroup analyses by region and risk of bias showed differences but did not resolve heterogeneity.
Conclusions:
- Prospective studies strongly associate hs-cTn with CAD risk and improved prediction.
- Further molecular and clinical research is needed to elucidate the mechanisms underlying hs-cTn's role in CAD.
- Robust methodologies and detailed data are crucial for understanding hs-cTn's interactive aspects in CAD patients.
Background And Objectives:
Previous studies suggest a link between high-sensitive cardiac troponin (hs-cTn) levels and coronary artery disease (CAD). However, the nature of this relationship is disputed. To address this, we conducted a study to gather and assess evidence on the association between hs-cTn and CAD prediction.
Data Sources:
Studies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After the screening, the selected articles' quality and risk of bias assessment were evaluated.
Synthesis Method:
Meta-analysis calculated std. mean difference on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed.
Results:
Twenty-two studies were included in this systematic review, with a total of 844 cases and 2101 control people. The results of the meta-analysis on nine studies showed a significant and positive association between hs-cTn levels and CAD (pooled std. mean difference = 0.44; 95% confidence interval = 0.14-0.73; p < 0.003), with no publication bias (p = 0.9170). Among subgroups, std. mean differences were notably different only when the data were stratified by region or risk of bias; however, subgroup analysis could not determine the source of heterogeneity.
Conclusions:
Available prospective studies indicate a strong association of hs-cTn with the risk of CAD and significant improvements in CAD prediction. Further investigations in both molecular and clinical fields with proper methodology and more detailed information are needed to discover more evidence and underlying mechanisms to clear the interactive aspects of hs-cTn level in CAD patients.
Related Concept Videos
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:20Imaging Studies for Cardiovascular System III: X-Ray
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
01:17Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
01:26Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...