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Updated: Jun 20, 2026

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Wet Chemistry and Peptide Immobilization on Polytetrafluoroethylene for Improved Cell-adhesion
Published on: August 15, 2016
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Site-selective peptide functionalisation mediated via vinyl-triazine linchpins
Jack D Sydenham1, Hikaru Seki1, Sona Krajcovicova1,2
1Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK. spring@ch.cam.ac.uk.
Abstract:
Herein we introduce 3-vinyl-1,2,4-triazines derivatives as dual-reactive linkers that exhibit selectivity towards cysteine and specific strained alkynes, enabling conjugate addition and inverse electron-demand Diels-Alder (IEDDA) reactions. This approach facilitates site-selective bioconjugation of biologically relevant peptides, followed by rapid and highly selective reactions with bicyclononyne (BCN) reagents.

