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Updated: Aug 15, 2026

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach
11:11

Identification of Novel CK2 Kinase Substrates Using a Versatile Biochemical Approach

Published on: February 21, 2019

Selective Inhibition of CK2: Emerging Strategies and Future Directions

Aryaman R Sokhal1, Sona Krajcovicova1,2, Jessica Iegre1

  • 1Yusuf Hamied Department of Chemistry, University of Cambridge, CambridgeCB2 1EW, United Kingdom.

Journal of Medicinal Chemistry
|August 13, 2026
PubMed
Summary

Developing selective inhibitors for Casein Kinase 2 (CK2) is crucial for treating cancer and neurodegenerative diseases. Novel strategies targeting the CK2α/β interface and the αD pocket have yielded promising dual-site inhibitors, with one now in clinical trials.

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