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Updated: Aug 5, 2026

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

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Cysteine Re-bridging Using Divinyl Pyrimidine Reagents for the Generation of Antibody-Drug Conjugates

Thomas Wharton1, Sona Krajcovicova1, David R Spring2

  • 1Yusuf Hamied Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK.

Methods in Molecular Biology (Clifton, N.J.)
|August 1, 2026
PubMed

Keywords:
Antibody characterizationAntibody-drug conjugatesCysteine conjugationDisulfide re-bridgingDrug-to-antibody ratio

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