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Aminoacyl-tRNA synthetase interactions in SARS-CoV-2 infection
1Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, U.S.A.
Biochemical Society Transactions
|December 18, 2023
Summary
Aminoacyl-tRNA synthetases (aaRSs) are crucial for protein synthesis and have non-canonical roles. SARS-CoV-2 interacts with host aaRSs, including a complex that binds viral RNA, impacting COVID-19.
Area of Science:
- Biochemistry
- Molecular Biology
- Virology
Background:
- Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes for protein synthesis.
- aaRSs also perform critical non-canonical functions in cellular processes.
- Viruses, including SARS-CoV-2, interact with host aaRSs for their life cycle.
Conclusions:
- Host aaRSs are integral to the SARS-CoV-2 life cycle through both known and novel mechanisms.
- The identified aaRS-RNA interactions represent a significant aspect of viral pathogenesis.
- Further research into these interactions may reveal new therapeutic targets for COVID-19.
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