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Updated: Jul 8, 2025

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
Long-term postoperative opioid use in orthopaedic patients
Eward J Melis1, Johanna E Vriezekolk2, Julian C C van der Laan1
1Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands.
Long-term opioid use after orthopaedic surgery affects 12.5% of patients, with one in thirty becoming new users. Pre-operative opioid use and body region impacted long-term use, highlighting the need for perioperative support.
Area of Science:
- Orthopaedic Surgery
- Pain Management
- Public Health
Background:
- Long-term opioid use post-orthopaedic surgery has a wide prevalence (1.4%-24%).
- Previous studies relied on prescription data, limiting accurate estimation of the problem's scale.
- Patient-reported measures offer a more robust method for assessing long-term opioid use.
Purpose of the Study:
- To determine the prevalence of long-term opioid use after orthopaedic surgery.
- To identify predictors of long-term postoperative opioid use.
- To utilize online patient-reported measures for a comprehensive assessment.
Main Methods:
- Prospective cohort study of adult patients undergoing orthopaedic surgery.
- Online survey administered six months post-surgery to assess current opioid use and willingness to taper.
- Demographic, clinical, and pre-operative opioid use data extracted from patient files.
Main Results:
- 12.5% of patients (76/607) reported opioid use six months post-surgery.
- 3.3% of patients (20/607) were new long-term opioid users (no pre-operative use).
- Pre-operative opioid use (OR=35.33) and affected body region (ORs: 6.84-12.75) were significant predictors.
Conclusions:
- 12.5% prevalence of long-term opioid use, with 1 in 30 becoming new users.
- Pre-operative opioid use and affected body region are key predictors.
- Long-term opioid users desire to taper, underscoring the need for perioperative prevention and support.
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