Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

1.6K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
1.6K
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

2.3K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
2.3K
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

2.5K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.5K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:28

Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla

1.3K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
1.3K
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

422
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
422
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

419
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
419

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-Reported Symptom Burden Among Thyroid Cancer Survivors: Retrospective Cohort Study.

JCO clinical cancer informatics·2026
Same author

CT Perfusion Blood Flow Provides an Early Response Marker for Progression-free Survival in a Prospective Randomized Clinical Trial of Metastatic Renal Cell Carcinoma.

Technology in cancer research & treatment·2026
Same author

Qualitative perspectives of early surgeon users on the value of the daVinci 5 surgical system.

Journal of robotic surgery·2026
Same author

Head and Neck Cutaneous Melanoma: Is Reduced Radial Margin of Excision Safe?

Plastic surgery (Oakville, Ont.)·2026
Same author

Age-specific differences in parathyroidectomy after implementation of guidelines for primary hyperparathyroidism.

Gland surgery·2026
Same author

Correction: Improving the therapeutic efficacy of sorafenib for hepatocellular carcinoma by repurposing disulfiram.

Frontiers in oncology·2026

Related Experiment Video

Updated: Jul 8, 2025

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

23.5K

Beyond the three P's: adrenal involvement in MEN1.

Uriel Clemente-Gutierrez1, Carolina R C Pieterman2, Michael S Lui1

  • 1Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Endocrine-Related Cancer
|December 18, 2023
PubMed
Summary

Adrenal lesions (ALs) are common in multiple endocrine neoplasia type 1 (MEN1). Most ALs do not progress, but malignancy should be suspected based on size and growth rate, warranting hormonal work-up.

Keywords:
adrenal incidentalomaadrenal nodulesadrenocortical carcinomamultiple endocrine neoplasia type 1

More Related Videos

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

460
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

18.9K

Related Experiment Videos

Last Updated: Jul 8, 2025

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

23.5K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

460
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

18.9K

Area of Science:

  • Endocrinology
  • Oncology
  • Medical Imaging

Background:

  • Adrenal lesions (ALs) are frequently observed in patients with multiple endocrine neoplasia type 1 (MEN1).
  • Clinical management guidelines for ALs in MEN1 are not well-established.
  • Understanding the prevalence and behavior of ALs in MEN1 is crucial for patient care.

Purpose of the Study:

  • To investigate the prevalence and clinical outcomes of adrenal lesions in patients with multiple endocrine neoplasia type 1.
  • To characterize the imaging features and growth patterns of ALs in MEN1.
  • To provide recommendations for the management and work-up of ALs in this population.

Main Methods:

  • Retrospective chart review of patients diagnosed with MEN1 between 1990 and 2021.
  • Classification of ALs based on imaging findings (unilateral/bilateral, nodular/diffuse, size).
  • Analysis of lesion growth, hormonal function, and clinical outcomes.

Main Results:

  • Out of 382 MEN1 patients, 89 (23.3%) had ALs, detected at a mean age of 47 years.
  • 101 measurable nodular lesions were identified, with a mean size of 17.5 mm; 26.7% were <1 cm.
  • Radiographic or clinical progression of ALs was uncommon; malignancy was suspected in cases with significant growth or size. Functional lesions were identified in 15.8% of those tested.

Conclusions:

  • Adrenal lesions in MEN1 patients are common but typically show slow progression.
  • Malignancy in ALs should be suspected based on lesion size and growth rate.
  • Baseline hormonal work-up is recommended; further biochemical testing is unnecessary for non-functioning lesions.