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Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

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Hierarchical Surface Pattern on Ni-Free Ti-Based Bulk Metallic Glass to Control Cell Interactions.

Fei-Fan Cai^1,2, Andreu Blanquer³, Miguel B Costa⁴

¹Department of Materials Science, Chair of Materials Physics, Montanuniversität Leoben, Jahnstraße 12, Leoben, A-8700, Austria.

Small (Weinheim an Der Bergstrasse, Germany)

|December 18, 2023

Summary

This summary is machine-generated.

Nickel-free titanium-based bulk metallic glasses (BMGs) offer excellent biocompatibility for biomedical uses. Thermoplastic forming (TPF) creates intricate micro/nano-patterns on these Ti-BMGs, enhancing cell interactions without compromising properties.

Keywords:

biocompatibility biomaterials bulk metallic glass patterning thermoplastic forming titanium alloys topography

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Published on: July 1, 2018

Area of Science:

Materials Science
Biomedical Engineering
Surface Engineering

Background:

Nickel-free titanium-based bulk metallic glasses (BMGs) are promising for biomedical applications due to their biocompatibility and mechanical strength.
The ability to precisely control surface topography is crucial for optimizing interactions between biomaterials and cells.

Purpose of the Study:

To demonstrate the versatility of thermoplastic forming (TPF) for creating micro/nano-patterns and hierarchical structures on Ti40Zr10Cu34Pd14Sn2 BMG.
To investigate the influence of different surface topographies on the biocompatibility and cellular response of Ti-BMGs.

Main Methods:

Fabrication of hierarchical structures using a two-step TPF process on Ti40Zr10Cu34Pd14Sn2 BMG.
Characterization of surface topographies, including micro- and nano-scale features.
In vitro biocompatibility testing using Saos-2 cell lines with Alamar Blue assay and live/dead analysis.

Main Results:

Successfully created hierarchical structures with 400 nm hexagonal close-packed protrusions on 2.5 µm square protuberances.
All tested surfaces (flat, micro-patterned, nano-patterned, hierarchical) exhibited good cell proliferation and viability.
Patterned surfaces promoted longer filopodia formation and induced star-shaped/dendritic cell morphologies.

Conclusions:

TPF is a versatile technique for fabricating complex surface topographies on Ti-BMGs.
Ti-BMGs with controlled surface patterns demonstrate excellent biocompatibility and influence cell morphology.
TPF-patterned Ti-BMGs offer a flexible platform for studying cell behavior on ordered surfaces for potential implant applications.