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Comments on "High-frequency spinal cord stimulation (10 kHz) alters sensory function and nerve fiber density in

Peng-Bo Zhou1,2, Wei Li1,2, Hong-Tao Sun1,2

  • 1The First School of Clinical Medical, Lanzhou University, Lanzhou, Gansu 730000, People's Republic of China.

Pain Medicine (Malden, Mass.)
|December 18, 2023
PubMed
Abstract

No abstract available in PubMed .

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

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