CLINICAL CHARACTERISTICS, TREATMENT MODALITIES, AND THEIR ASSOCIATION WITH LONG-TERM VISUAL OUTCOMES IN UVEAL...

Area of Science:

• Ophthalmology
• Retinal Diseases
• Uveitis

Background:

• Uveal effusion syndrome (UES) is a rare condition causing fluid buildup in the eye's uveal layer.
• Understanding UES subtypes and their impact on vision is crucial for effective management.

Purpose of the Study:

• To investigate the clinical characteristics of nanophthalmic Type 1 UES (UES-1) and non-nanophthalmic Type 2 UES (UES-2).
• To compare treatment modalities and their association with long-term visual outcomes in UES patients.
• To identify prognostic factors for vision loss in UES.

Main Methods:

• A retrospective cohort study of 23 eyes with UES treated between 2005 and 2023.
• Comparison of clinical features and visual outcomes between UES-1 and UES-2.
• Logistic regression analysis to determine factors associated with vision loss.

Main Results:

• Retinal pigment epithelium mottling was more frequent in UES-1.
• UES-1 showed decreased visual acuity and increased macular thickness post-treatment.
• UES-2 demonstrated improved visual acuity and reduced subfoveal choroidal thickness and subretinal fluid height.

Conclusions:

• UES type is the sole independent prognostic factor for vision loss.
• Treatment modalities did not significantly impact visual outcomes in this study.
• UES-2 is associated with a lower risk of vision loss compared to UES-1.