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Overview and Recommendations for Prospective Multi-institutional Spatially Fractionated Radiation Therapy Clinical
Heng Li1, Nina A Mayr2, Robert J Griffin3
1Department of Radiation Oncology, John Hopkins University, Baltimore, Maryland.
International Journal of Radiation Oncology, Biology, Physics
|December 18, 2023
Summary
Spatially fractionated radiation therapy (SFRT) shows promise but requires standardized planning and reporting. This consensus developed recommendations to overcome obstacles for future multi-institutional clinical trials of SFRT.
Area of Science:
- Radiation Oncology
- Medical Physics
- Radiobiology
Background:
- Spatially fractionated radiation therapy (SFRT) offers a novel approach to cancer treatment with promising early outcomes.
- However, the heterogeneity of SFRT dose delivery presents challenges compared to standard radiation therapy.
- A lack of prospective multi-institutional clinical trials hinders broader SFRT adoption.
Purpose of the Study:
- To develop consensus recommendations for dosimetric planning, delivery, and dose reporting of SFRT.
- To address current obstacles impeding the design and execution of SFRT clinical trials.
- To facilitate standardization across institutions for SFRT research.
Main Methods:
- Formation of working groups comprising radiation oncologists, radiobiologists, and medical physicists with SFRT expertise.
- Review of existing SFRT technologies, methods, and clinical trial barriers.
- Consensus-building process to identify key areas for improvement.
Main Results:
- Identified challenges in SFRT availability, treatment planning system support, and physics/dosimetry guidance.
- Highlighted limitations in radiobiological modeling and prescription/combination strategies for SFRT.
- Acknowledged the need for standardized reporting of SFRT parameters.
Conclusions:
- Recommended improvements in clinical practice guidance documents for SFRT.
- Emphasized the need for enhanced treatment planning system support and reporting templates.
- Advocated for the development of improved radiobiological models and multi-institutional clinical trials.
