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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Related Experiment Video

Updated: Jul 8, 2025

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
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Peripapillary Perfusion Analysis Using Optical Coherence Tomography Angiography in Patients with Normal Tension

Do Young Kim1,2, Soojin Kim1,2, Sang Ah Kim1

  • 1Siloam Eye Hospital, Seoul, Korea.

Korean Journal of Ophthalmology : KJO
|December 18, 2023
PubMed
Summary

Vascular parameters in the optic nerve head are reduced in normal tension glaucoma (NTG) and correlate with retinal nerve fiber layer thickness. This reduction worsens with glaucoma severity, suggesting OCT angiography

Keywords:
Low tension glaucomaOptic nerve head perfusionOptical coherence tomography angiography

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Medical Imaging

Background:

  • Normal tension glaucoma (NTG) is a progressive optic neuropathy.
  • Assessing optic nerve head (ONH) vascularity is crucial for glaucoma diagnosis and management.
  • Optical coherence tomography angiography (OCTA) offers advanced visualization of ONH microvasculature.

Purpose of the Study:

  • To evaluate differences in ONH perfusion parameters in normal tension glaucoma (NTG) across disease stages.
  • To correlate these vascular parameters with peripapillary retinal nerve fiber layer (RNFL) thickness.
  • To determine the utility of OCT angiography in assessing glaucoma severity.

Main Methods:

  • Retrospective analysis of 83 eyes with NTG (mild, moderate, severe) and 90 healthy eyes.
  • Quantification of optic nerve head perfusion density (PD) and flux index (FI) in four sectors using OCT angiography.
  • Comparison of vascular, structural, and functional parameters; subgroup analysis by NTG stage; correlation analysis with RNFL thickness.

Main Results:

  • Significantly reduced PD and FI in the NTG group compared to healthy controls.
  • Vascular parameter reduction was evident across most ONH sectors, with notable exceptions.
  • Inferior PD significantly decreased across all NTG severity levels.
  • PD and FI showed strong correlations with RNFL thickness in all quadrants, particularly the inferior region.

Conclusions:

  • Vascular parameters are significantly diminished in glaucomatous eyes, with the degree of reduction proportional to disease severity.
  • OCT angiography-based peripapillary perfusion analysis can complement existing glaucoma diagnostic tools.
  • These findings highlight the role of vascular dysfunction in NTG pathogenesis and progression.