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Updated: Jul 8, 2025

Murine Model of Allergen Induced Asthma
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Machine Learning Approaches to Predict Asthma Exacerbations: A Narrative Review
Nestor A Molfino1, Gianluca Turcatel2, Daniel Riskin3
1Global Development, Amgen Inc., One Amgen Center Dr, Thousand Oaks, CA, 91320, USA. nmolfino@amgen.com.
Artificial intelligence (AI) and machine learning (ML) can predict asthma exacerbations by analyzing diverse patient data. Further research is needed to explore AI/ML
Area of Science:
- Healthcare technology
- Computational medicine
- Respiratory medicine
Background:
- Asthma management remains challenging despite advances, with many patients experiencing acute exacerbations.
- Disease activity is influenced by numerous factors including medical history, environment, and patient habits.
- Current asthma treatment regimens do not fully prevent exacerbations.
Purpose of the Study:
- To review the current evidence of artificial intelligence (AI) and machine learning (ML) in asthma management.
- To explore the potential of AI and ML in predicting asthma exacerbations.
- To identify future applications and challenges of AI/ML in clinical asthma care.
Main Methods:
- Literature review of existing scientific evidence on AI and ML in asthma.
- Analysis of studies demonstrating AI/ML's predictive capabilities for asthma exacerbations.
- Synthesis of factors influencing asthma exacerbations and their integration into AI/ML models.
Main Results:
- AI and ML show promise in accurately predicting asthma exacerbations.
- These technologies can integrate a wide range of patient-specific data for comprehensive analysis.
- Existing research highlights the potential but also the limitations of current AI/ML applications.
Conclusions:
- AI and ML offer a promising approach to revolutionize personalized asthma management.
- Clinical application of AI/ML in asthma care is still in its early stages.
- Further research is essential to overcome implementation barriers and optimize AI/ML for asthma exacerbation prediction.
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