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[Polypharmacy in acute and chronic kidney diseases]
Roxana Manaila1, Andrea Huwiler2
1Institut für Pharmakologie, Universität Bern, Inselspital, INO-F, 3010, Bern, Schweiz.
Innere Medizin (Heidelberg, Germany)
|December 19, 2023
Summary
Chronic kidney disease (CKD) patients face high risks from polypharmacy, defined as taking five or more daily medications. Managing multiple drugs is crucial to prevent adverse effects and improve patient outcomes.
Area of Science:
- Nephrology
- Clinical Pharmacy
Context:
- Chronic kidney disease (CKD) prevalence is rising globally.
- CKD is linked to numerous comorbidities requiring complex medication regimens.
- Patients with CKD are at high risk for polypharmacy (≥5 daily medications).
Purpose:
- To summarize the challenges of polypharmacy in CKD patients.
- To discuss strategies for identifying and managing inadequate polypharmacy.
- To highlight the implications of polypharmacy in acute kidney injury.
Summary:
- Polypharmacy in CKD increases the risk of adverse drug effects and drug-drug interactions.
- Inadequate medication management can lead to increased morbidity and mortality.
- Addressing polypharmacy complexity, treatment burden, and nonadherence is essential.
Impact:
- Improved identification of patients with inadequate polypharmacy.
- Reduced risk of adverse drug events and drug interactions in CKD.
- Enhanced medication safety and therapeutic benefits for CKD patients.
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