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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Hormone Replacement Therapy and Psoriasis Risk: A Nationwide Population-Based Cohort Study.

Gang Min Go1, Hyun Ju Oh2, Kyungdo Han3

  • 1Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Journal of Korean Medical Science
|December 19, 2023
PubMed
Summary
This summary is machine-generated.

Hormone replacement therapy (HRT) may increase the risk of developing psoriasis in post-menopausal women. Prolonged HRT use, especially for five or more years, showed a significantly higher likelihood of psoriasis development.

Keywords:
Cohort StudyEpidemiological StudyHormone Replacement TherapyPsoriasisRisk Factor

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Area of Science:

  • Dermatology
  • Endocrinology
  • Public Health

Background:

  • Hormone replacement therapy (HRT) is prescribed for menopause symptom relief.
  • Existing research links HRT to cardiovascular disease and cancers.
  • The association between HRT and psoriasis risk remains unestablished.

Purpose of the Study:

  • To investigate the potential link between HRT and the risk of developing psoriasis.
  • To determine if HRT duration influences psoriasis risk in post-menopausal women.

Main Methods:

  • Nationwide population-based cohort study.
  • Utilized national health insurance database including 1,130,741 post-menopausal women.
  • Stratified participants into four groups based on HRT duration for risk analysis.

Main Results:

  • Incidence rates of psoriasis were 3.36 and 4.09 per 1,000 person-years for no HRT and ≥ 5 years of HRT, respectively.
  • Adjusted analysis revealed a significantly increased risk of psoriasis for the ≥ 5 years HRT group (HR, 1.22; 95% CI, 1.16-1.29).
  • Risk was adjusted for age, lifestyle factors, and comorbidities.

Conclusions:

  • Post-menopausal HRT use is associated with an elevated risk of psoriasis.
  • Longer duration of HRT may correlate with a higher likelihood of psoriasis development.