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Serious Adverse Events and Laboratory Monitoring Regimens for Outpatient Parenteral Antimicrobial Therapy With
Shawnalyn W Sunagawa1,2, Sarah Arduser1,2, Molly M Miller1
1Department of Pharmaceutical and Nutrition Care, Nebraska Medicine, Omaha, Nebraska, USA.
Open Forum Infectious Diseases
|December 19, 2023
Abstract:
The optimal laboratory monitoring frequency for outpatient parenteral antimicrobial therapy-related adverse events (OPAT-AEs) during cefazolin and ceftriaxone therapy is not well defined. We identified 2.7 OPAT-AEs per 1000 sets of weekly laboratory tests in this population, suggesting that less intensive laboratory monitoring may be safe and reasonable.
Insights
Optimizing laboratory monitoring for outpatient parenteral antimicrobial therapy (OPAT) with cefazolin and ceftriaxone is crucial. Findings suggest that less frequent lab tests may be safe, reducing healthcare burdens.
Area of Science:
- Infectious Diseases
- Clinical Pharmacology
- Pharmacovigilance
Background:
- Outpatient parenteral antimicrobial therapy (OPAT) is common for various infections.
- Monitoring for adverse events (AEs) during OPAT is essential but resource-intensive.
- Optimal laboratory monitoring frequency for OPAT-AEs during cefazolin and ceftriaxone therapy is not well established.
Purpose of the Study:
- To evaluate the incidence of OPAT-related adverse events (OPAT-AEs) in relation to laboratory monitoring frequency.
- To determine if less intensive laboratory monitoring is safe and reasonable for patients on cefazolin and ceftriaxone OPAT.
Main Methods:
- Retrospective analysis of laboratory test data and identified OPAT-AEs.
- Calculation of OPAT-AE incidence per 1000 sets of weekly laboratory tests.
- Focus on patients receiving cefazolin or ceftriaxone for OPAT.
Main Results:
- An incidence of 2.7 OPAT-AEs per 1000 sets of weekly laboratory tests was identified.
- This low incidence suggests a potential for reduced monitoring frequency.
- The study provides data to inform evidence-based monitoring guidelines.
Conclusions:
- Current laboratory monitoring frequency for cefazolin and ceftriaxone OPAT may be higher than necessary.
- Less intensive laboratory monitoring appears to be safe and reasonable for this patient population.
- Further research could refine monitoring protocols to optimize patient care and resource allocation.
Keywords:
adverse eventscefazolinceftriaxonelaboratory techniques and proceduresoutpatient parenternal antimicrobial therapyMore Related Videos
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