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Magnetic Nanoparticles Mediated Thrombolysis-A Review
1Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695 USA.
IEEE Open Journal of Nanotechnology
|December 19, 2023
Summary
Magnetic nanoparticles offer targeted thrombolysis for thrombosis. This review explores their use in vitro and in vivo, including dual-mode approaches with acoustic fields, for enhanced clot dissolution.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cardiovascular Research
Background:
- Thrombosis treatment demands effective, targeted therapies.
- Magnetic nanoparticles (MNPs) are increasingly explored for medical applications.
- Limited reviews exist on MNPs for thrombolysis.
Purpose of the Study:
- To review the current applications of MNPs in thrombolysis.
- To explore MNP-mediated thrombolysis under static/dynamic magnetic fields.
- To discuss dual-mode thrombolysis combining MNPs and acoustic fields.
Main Methods:
- Review of in vitro and in vivo studies on MNP-mediated thrombolysis.
- Analysis of MNP navigation and control using magnetic fields.
- Examination of combined MNP-acoustic field thrombolysis.
Main Results:
- MNPs show promise for targeted thrombolysis.
- Magnetic fields enable MNP navigation and trapping for clot dissolution.
- Dual-mode thrombolysis enhances therapeutic efficacy.
Conclusions:
- MNP-mediated thrombolysis is a developing field with significant potential.
- Further research can optimize MNP targeting, drug release, and clot disruption.
- This review provides insights for future clinical development of MNP-based therapies.
